Ulsan EIP center have designed research and development into business (R&DB) framework aiming at an effective expansion of symbioses in industrial complexes. Based on the framework, the EIP region center has facilitated fourty symbioses till date, out of which the 13 networks are now in operation, 20 has under negotiation or design, and seven under feasibility evaluation. In 2005, South Korea has initiated an ambitious 15 year 3 phase EIP project carried under the leadership of the Korea National Cleaner Production Center (KNCPC).Ulsan EIP center devised the R&DB framework To develop the symbiotic networks through a feasibility study To negotiate with the stakeholders to reduce the risks of networks failing To attract tenants by overcoming barriers and an equivalent benefit sharing among the participants in the synergy networks Rules and principles of the critical activities(i) Rules followed during the selection of potential partners. The potential partners are selected based on their geographic proximity and willingness to participate/cooperate in the synergy development(ii) Rules followed in the business model development. The most important step prior to the implementation is the development of a suitable business model. The factors that are considered to be important are as follows: (i) industrial symbiosis can be achieved with the currently available technology, (ii) benefits should overcome and exceed the investments (iii) industrial symbiosis activities must be allowed under the existing laws.(iii) Principles followed during negotiation. Most delicate step prior to implementation is the negotiation among the key partners participating in the network. According to the principles that are put-forth, the sharing of benefits among the partners should be equivalent based on the value created in the synergy. Benefit is proportionately shared based on their investments in the infrastructure development for a particular synergy network. Minimizing various risks of failure led to the gradual, yet smooth establishment of the designed networks.