Dismutase, Sod2, reduces the amount of reactive oxygen species, ROS, present in
the mitochondria by converting superoxide to molecular oxygen and hydrogen
peroxide (SGD). Increased amounts of ROS in the mitochondria causes DNA damage,
thus affecting cellular functions leading to apoptosis. ROS has shown to impact
aging; accumulation of DNA damage due to ROS can lead to age-related diseases
and increased aging (Melov). Additionally, Sod2 levels vary with superoxide
presence; these variations have been shown to impact tumor cells (Skrzycki). The ability to manipulate Sod2
would prove to be valuable in the fight to extend lifespan and surmount cancer.