Platelets/Blood clotting factors The role of platelets is that

Platelets/Blood clotting factors

The role of platelets is that it helps the blood to clot at a wound. If
the blood vessel wall is damaged, platelets seal and clot the wound which stop
the blood cells to be lost and it also helps to prevent pathogens entering the
blood via the wound. Platelets are used to treat
bone marrow failure and leukaemia. It is also used for following a transplant
or chemotherapy treatments. In addition,
it is needed during pregnancy as there will be shortage of platelets and it is
used for thrombocytopenia (low
platelet count caused by cancer, anaemia or viral infection. Also, it is used
for bacteria in the blood, medication, liver
disease (clotting proteins are affected in blood plasma) and sepsis (low platelet count and cause
abnormal clotting). Haemophilia disease
can be treated with factor VIII transfusion and this is a blood clotting
protein. This is also known as anti-haemophilic factor (AHF).The process of blood clotting (coagulation) involves
blood vessel being damaged first and then plasma fibrin starts to make sticky
threads. Then, it allows the platelets and other blood cells to be trapped
which then enable the formation of blood clot. Hard scab is then formed and
tissue below is fixed and repaired. Finally, scab falls off and scar is made.

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Thrombocytopenia condition is caused when the blood contains low number of platelets. Platelets are
also known as thrombocytes which are created in the bone marrow and it help
with the clotting of blood. The person will bleed a lot if they have a low
number of platelets in the blood. In addition, people can have thrombocytopenia
when the spleen become large or when they have cancer like leukaemia. This can
make the platelet number in the blood to decrease. Chemotherapy treatment uses drugs which can results in blood having
low number of platelets. Platelets transfusion
is used for this type of condition to increase the number of platelets in the
blood.

The liver helps with blood
clotting and it produces different proteins such as protein c and it also
produces coagulation factors such as factor V and XI. Liver disease can decrease
the number of proteins and coagulation factors within the blood therefore, blood clotting factors transfusion is
used to increase the protein and coagulation factors in the blood to help with
the clotting process. Sepsis is a
condition that causes low number of platelets in the blood and lead to abnormal clotting. If it is not treated,
it leads to failure of the organ and even causes death. Therefore, platelets transfusion can be used to
increase the number of platelets in the blood.

Intravenous immune
globulin (IVIG)

Immunoglobin is blood proteins mixture which is known as antibodies
and they are created with the help of our immune system. Immunoglobin helps to
fight against infection or disease. Immunoglobin that is liquid is derived from
the donors of blood plasma via their vein (arm) and they are screened and
checked to ensure that they are healthy. They are screened to see if they carry
serious infections such as AIDS and hepatitis.
The blood plasma then purified to be
for IVIG therapy. It requires 1000
of human donors to produce one dose. In addition, IVIG can be used to treat
both primary and secondary immune
deficiencies such as infections, autoimmune and disorders
(neuroimmunological).IVIG treatment
can help to strengthen the immune system
that are weak therefore, the person can fight over infections and be healthy. This
treatment can be used to treat different autoimmune disorder which affects CNS
such as multiple sclerosis.

When Immunoglobin is derived from
the blood plasma and IgG type is
removed from the blood plasma that is donated. Also, IgG helps to fight against bacteria and virus and it contain other effects so, it can be used
for autoimmune problems. Some people choose to have IVIg than other medications
like corticosteroids, immunosuppressant and biologic drugs in order to treat
their immune problems. Furthermore, IVIg can be taken other medications such as
immunosuppressant. Our immune system can normally produce enough antibodies to fight against germs that
lead to infections however, our body cannot be able to produce enough
antibodies when we have immune deficiency therefore, you will have a higher
risk of getting infections. IVIg helps to gives antibodies to fight over the
infections. Moreover, autoimmune diseases such as lupus can help the body to increase
the red blood cell counts and low red cell counts can lead to anaemia. IVIg can
help to prevent the WBCs of people with lupus from damaging their RBCs. Both
adults and children can receive this IVIg therapy.