Moreover, inhibitory effects against growth of Salmonella typhyi ,

Moreover,
liquorice exhibits antibacterial, antifungal and antiviral properties. Over the past two decades fungal infections
have evolved into important cause of morbidity and mortality in modern
medicine. The prevalence of resistance to antifungal agents has significantly
increased. So, it makes it necessary to discover new classes of antifungal
compounds to treat fungal infections. There are reports which have indicated that
ethanolic extract of Glycyrrhiza glabra has got a very good anti-mycotic
activity against Candida albicans (Anagha
et al. 2014).  Also , oral liquorice preparations containing
glycyrrhetinic acid, are used for the treatment of viral infections, viral
hepatitis and common cold. Liquorice extracts have been used for more than 60
years in Japan to treat chronic hepatitis, and also have therapeutic benefit
against other viruses, including human immunodeficiency virus (HIV) and  cytomegalovirus (CMV)(M.
Packia Lincy, K. Paulpriya 2013) .  Licorice also 
has a prominent antiviral
activity as it does not allow the virus cell binding. It has been reported as (HIV-1)
Japanese encephalitis virus
and yellow fever virus (Parvaiz
et al. 2014).   Besides, the extracts of the roots of
liquorice has shown magnificent antibacterial effect against two gram-positive
(Bacillus subtili and Staphylococcus aureus) and two
gram-negative (Escherichia coli and Pseudomonas aeruginosa)
bacteria by using the well diffusion method (Nitalikar
et al. 2010). Also, liquorice extract shown in
vitro inhibitory effects against  growth
of  Salmonella typhyi  , Salmonella 
paratyphi B , Shigella sonnei , Shigella flexneri and entertoxigenic
E.coli  but ,  Salmonella  paratyphi B showed  no susceptibility to liquorice with
concentration lower than 7.5% , however all previous tested bacterial strains
exhibited susceptibility to high concentration of liquorice.  So , the results obtained from previous  study showed that liquorice can be considered
as an alternative herbal antibacterial agent against the bacterial strains that
was  investigated using well and disc
diffusion method (Shirazi
et al. 2007). In another study  Glabridin and  Flavanoid constituent of the herb has
inhibitory activity (in vitro) against Helicobacter pylori ,  which is now known to be involved in the
pathogenesis of some cases of gastritis and peptic ulcer(M.
Packia Lincy, K. Paulpriya 2013).    In addition, liquorice root extract might be useful as antibacterial
agents against oral pathogens. It’s can inhibit the growth of Streptococcus
mutans, Actinomyces viscosus, Streptococcus sanguis  and Enterococcus
faecali(Sedighinia et al. 2012).