Background: drug carriers for antimicrobial therapy. Methods: In this

Background: Essential oilslike Achilleamillefolium (common yarrow) has been used in manyapplications such as medicine, veterinary science, and cosmetics 1.

The most of EOsare poorly soluble in water, biologically unstable and they distributedefectively to target sites. Due to a lackof stability of most of the essential oils, new methods have been developed toimprove their stability, among these is the encapsula­tion of the essentialoils in liposomes 2. Liposomes are vesicles composed of concentricphospholipid bilayers 3. Due to their capability to deliver slow drugrelease, cutaneous targeting and extended transdermal delivery of drugs,liposomes have been reported to be promising drug carriers for antimicrobial therapy.Methods: In this study, nanoliposomescontaining Achilleamillefolium essential oil were prepared by thin-filmhydration method using Soybean phosphatidylcholine and cholesterol and fullycharacterized for their size, polydispersity index, zeta potential andmorphology by different instrumental techniques. Results: According to FTIRand DSC results, no interaction was observed between encapsulated Essentialoils and liposome constituents. The particle size and size distributionwere calculated 110–140 nm and 0.

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21–0.32, respectively. Inoptimized formulation, the encapsulation efficiency of Achilleamillefolium essentialoil was calculated about 60%.

The liposomes were tested for theirstability after storing them for 2 months at 4 °C by monitoring changes intheir mean size, polydispersity index and encapsulation efficiency (EE) values.It was found that liposomes exhibited nanometric oligolamellar and sphericalshaped vesicles.Conclusion: This studyconcluded that the presence of Achilleamillefoliumin liposomes may effectively enhance its stability and theentrapped oil remains stable for an extended period of time. Liposomal gelformulation of essential oils may also lead to improved and betterantimicrobial activity.